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Introduction Definition movement disorder characterized by Parkinson-plus syndromes multiple system atrophy progressive supranuclear palsy corticobasal degeneration (CBD) Associated conditions dementia depression sleep disorders Pathogenesis Loss of dopaminergic neurons in the substantia nigra leads to dopamine depletion in the striatum this creates an imbalance between dopamine and acetylcholine resulting in improper muscle movement Impaired degradation of -synuclein can lead to degradation of dopaminergic striatal neurons Presentation bradykinesia muscle rigidity postural instability resting tremor Studies Differential Huntington disease differentiating factor Essential tremor differentiating factor Drug-induced Parkinsonism Treatment Medical Operative deep brain stimulation Complications Dementia Sleep disorders Falls Create a free account or log in to see the cards.