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Description

Both pyruvate and FAs serve as primary fuel sources in the TCA cycle [146], but -oxidation of FAs generates energy and ROS through the production of acetyl-CoA [147]

In cohort 3, 16 eyes showed improvement in MMS and heatmaps (Figure 7, AD, and Supplemental Figures 3438, 4046, and 4849) and 2 eyes showed little change or worsening (Supplemental Figures 39 and 47)