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Figure 1 Accumulating evidence indicates that distinct microbial communities differentially regulate T cell-mediated immunity

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Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC

To address this, we generated an in vitro model of CMT2/SORD MNs by reprogramming carrier and patient fibroblasts ( SORD c.757delG/wt , SORD wt/c.316_425+165del , and SORD c.757delG/c.316_425+165del , indicated as SORD +/- #1, SORD +/- #2 and SORD -/- #1, respectively) into induced pluripotent stem cells (iPSCs)

Circular RNAs (circRNAs) are a special class of single-stranded non-coding RNAs featuring stable covalent closed-loop structures that resist degradation by RNA nucleases [156]

Clinical Trial Findings: Quantification of Cytokines IFN-, TNF-, IL-2, and IL-10 Levels in Plasma and PBMCs From T2DM Subjects Levels of cytokines IFN-, TNF-, IL-2, and IL-10 were quantified in plasma and PBMCs isolated from T2DM subjects at pre- and post- L-GSH/or placebo supplementation