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Studies have shown that heat shock protein A12A (HSPA12A) in hepatocytes can effectively alleviate liver IRI pathological damage by inhibiting glycolysis-mediated HMGB1 lactylation and hepatocyte secretory activity, thereby weakening the chemotaxis and activation ability of macrophages

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Interestingly, epidemiological studies corroborated this observation in humans as well (Myers and Davidson, 2000), reinforcing the idea that the developing CNS is most susceptible to the deleterious effects of MeHg

A recent report revealed that ferroptosis inducers, such as RSL3 and erastin, induced the ASK1-p38 MAPK pathway activation downstream of lipid ROS in A549 cells [43]

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Scientists need to carry out more research before they can conclusively determine whether supplements can treat infertility.