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doi: 10.3389/fgene.2020.566244 Received 16 July 2020 Accepted 07 September 2020 Published 02 October 2020 Volume 11 - 2020 Edited by Giovanni Cenci, Sapienza University of Rome, Italy Reviewed by Daniel Vaiman, Institut National de la Sant et de la Recherche Mdicale (INSERM), France

Treatment programmes can be adjusted according to the patients response to treatment, to emphasise other areas once improvements have begun to appear

The GHIS Multicenter Study Group (2006) Once daily rhIGF-I/rhIGFBP-3 treatment improves growth in children with severe primary IGF-I deficiency: results of a multicenter clinical trial