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If so, the CK1-mediated phosphorylation of Axin S359 alone would initiate or, in conjunction with the phosphorylation of Axin T384, downregulate Wnt signaling providing a context-dependent phosphorylation switch that would be interesting to test in future studies

Psychopharmacol Bull

The loss of pigmented neurons, the decrease of TH-ir, and the increase in both iNOS and caspase-3 immunoreactivities were markedly increased by administering both rotenone and LPS