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In practice, [hydroquinone] compounded up to 8% is considered to be high and is only recommended for short periods of time, says Lesley Clark-Loeser, MD, a board-certified dermatologist in Davie, Florida

Front Neurosci 12:930

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Polymeric nanoparticles fabricated from biodegradable materials such as poly (lactic-co-glycolic acid) (PLGA) enable controlled release over days to weeks, sustaining drug levels in anterior and posterior ocular compartments (Nagarwal et al., 2009)

The first bromodomain (BD1) binds to poly-acetylated histones, such as H4K5acK8ac, whereas the second bromodomain (BD2) selects for acetylated non-histone proteins 18,19,20