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doi: 10.1016/j.cub.2004.06.054 237 ShawRJBardeesyNManningBDLopezLKosmatkaMDePinhoRAet al

The mechanism of action of Acamprosate is modulating neurotransmitters in the central nervous system, particularly glutamate and gamma-aminobutyric acid (GABA), to reduce withdrawal symptoms and support long-term sobriety

You replace the cartridge when it empties and attach a new needle for each injection

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Some maintain their protective function, and under conditions of mild or moderate stress, they may even revert from a neurotoxic to a neuroprotective profile 18,155