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In the TME, MDSCs can survive in a high ROS environment because of their high expression of NRF2

In ALS pathogenesis, excitotoxic and oxidative crosstalk exists between motor neurons and glia

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Although the precise etiology of PD remains unclear, factors such as oxidative stress, lipid metabolism dysregulation, metal ion metabolic disorders, mitochondrial dysfunction, and glial cell activation are known to contribute to the progression of PD, suggesting that ferroptosis plays a significant role in its pathogenesis (Wang ZL

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