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L-methylfolate as adjunctive therapy for SSRI-resistant major depression: randomized, double-blind, placebo-controlled trial

[2] [6] In healthy adults, vitamin B 12 deficiency is not common, mainly because body stores of the vitamin are substantial and turnover is slow, with relatively low dietary requirements

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Zhang, X., Bao, J., Zhang, Y

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The magnitude of Chac1 downregulation exceeded that of canonical refeeding-responsive genes controlling hepatic glucose metabolism, such as the downregulation of G6pc or upregulation of Gck (Figure 6A), indicating robust transcriptional suppression of Chac1 during feeding