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Serious but less common risks may include: hypersensitivity reactions, hypokalemia (rare, with B12 correction of severe deficiency), and exacerbation of polycythemia

Related to cardiomyopathy, intramuscular sarcocystosis, intestinal sarcocystosis

A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program

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It is generally well-tolerated, though gastrointestinal side effects are common initially