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In individuals with Hashimotos, this heightened immune reaction may: Trigger systemic inflammation , leading to increased thyroid symptoms like fatigue, brain fog, and joint pain

DJ-1 directly binds to the nuclear subunit of mitochondrial complex I, as well as the mitochondrial DNA-encoded subunits NDUFA4 and ND1, and co-localizes with complex I

GSTM4-4

This happens because hormones like estrogen and testosterone drop, making it harder for the body to burn calories well

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B12 deficiency elevates homocysteine, a sulfur-containing amino acid that damages arterial endothelium and increases atherosclerosis risk