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When mTORC1 is inhibited by external interventions such as rapamycin, ULK1 activity is released, significantly enhancing the autophagic response

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This has been the case for TNX, where the association was found in a single patient with a complex phenotype due to his contiguous gene syndrome and where the genetics was not clear

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Retatrutide is an investigational compound it has not received FDA approval, and its long-term safety profile is still being evaluated through the TRIUMPH Phase 3 program