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There could be swelling and sores around the initial sore in early syphilis

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7 These reductions were not accompanied by systemic immunosuppression markers, suggesting local rather than systemic anti-inflammatory activity a profile more consistent with tissue-level NF-B pathway modulation than with global glucocorticoid-type immunosuppression

On the adjacent hydrophobic alpha-helical binding site on the C-terminal domain, the GST binds a hydrophobic xenobiotic molecule

doi: 10.1016/j.ijbiomac.2023.127708