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Capsaicin (CAPS) from hot chili peppers and mROS products from oxidative stress are the main stimulators of transient receptor potential (TRP) vanilloid 1 (TRPV1), while capsazepine (CAPZ) blocks it [16, 17]

These actions are likely complementary to the antioxidant mechanisms described above (227) in combatting neurodegenerative diseases

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The hepatoprotective effects observed in our study suggest that IF may offer additional benefits beyond inflammation control in patients with RA, potentially addressing comorbidities associated with metabolic dysfunction 16

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