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Things like stress, lack of sleep, poor diet, alcohol, smoking, and pollution speed up that depletion

Oral Vitamin B12 Replacement for the Treatment of Pernicious Anemia.

Its commonly used in clinics for those who need immediate benefits, such as detoxification or skin brightening

Not sure if you know this but it's worth mentioning that if you have any neurological symptoms when you were diagnosed, the B12 regime (according to all guidelines) is six loading doses of 1mg B12 and then 1mg injections every other day until no further improvement (for some people this takes many months)

References UNICEF

One such enzyme is cystathionine beta-synthase (CBS), which catalyzes the first and most important (rate-limiting) step in trans-sulfuration from homocysteine to cystathionine