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According to Walker and Dhillo , Ipamorelin mimics natural pulsatile GH release without overstimulation of cortisol or prolactin (Walker & Dhillo, Nature Reviews Endocrinology )

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However, a significant caloric deficit, especially one this pronounced, often comes at a cost: the loss of precious lean muscle mass

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That distinction matters because it should be used only when clinically appropriate and supervised by a provider