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However, because the metabolism of glutamine produces ammonia as a byproduct, taking excessively large single doses can overwhelm the liver's ability to process the nitrogen, leading to transient nausea, upper GI discomfort, or belching

NejatianMGhandehari YazdiAPFattahiRSaberianHBazsefidparNAssadpourEet al

These approaches aim not only to inhibit KRAS signaling directly, but also to eliminate oncogenic proteins or exploit vulnerabilities associated with KRAS-driven tumors

However, when the demand for ATP is lower than that for NAD + , this condition may result in damage to the ETC, which in turn may trigger increased O 2 production