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using a calculation methodology to account for the impact of improper payments in recalculating expenditures and payment amounts for certain Shared Savings Program financial calculations, upon reopening an ACO's payment determination and issuing a revised initial determination pursuant to 425.315(a), as described in section III.G.7.c of this final rule

Scabia, G

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Ethacrynic acid concentration screening in the cytoplasm of human hepatocytes The compounds were incubated in liver cytoplasm over a series of time points, and their status as GST substrates was determined by comparing their metabolic trends in the presence and absence of inhibitors