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Elevated HMGB1 levels have been detected in the blood of patients, where it interacts with receptors such as RAGE and TLR4, forming complexes with IL-1 or LPS to activate proinflammatory signaling pathways (Shimizu et al., 2017)

Multiple studies report that its effects on myoblast proliferation and migration are not abolished by blocking the IGF-1 receptor, implying that the isolated E-domain peptide acts through a different, non-IGF-1R route

3.3 Changes in gut microbial composition in Psoriasis Gut microbiome in all states (HCs, PSO) consisted of four dominant phyla: Firmicutes , Proteobacteria , Actinobacteriota , and Bacteroidota ( Figures 3A, B )

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Huang et al., 2014b)