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GSH plays a key role in cell resistance to oxidative damage to tissues and cells by minimizing the ROS concentration 34

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Together these results suggest that ORF3a induces mROS production to activate HIF-1, which in turn triggers a shift in cellular metabolism to favor glycolysis, resulting in increased viral replication and transcription of pro-inflammatory cytokines

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Nat Rev Mol Cell Biol 10:307318 Maes M (2009) Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms