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Methods: We analyzed the outcome of 36 children after second allo-HSCT with hematological malignancies: ALL-18 pts,AML-11pts,JMML-4pts,CML-1pt,MPAL-1 pt,sMDS -1 pt.First allo-HSCT was performed from MUD in 15 pts,MRD in 11 pts,haplo-donors in 9pts, syngeneic donor -1 pt.Condition regimen was MAC in 19 pts,RTC-5 pts and RIC in 12 pts.Indications for 2 nd allo-HSCT were relapse in 28 pts,graft failure (including pts with progression of the disease)-8 pts.Median age at the time of the first allo-HSCT was 5 y.o.(1-17),median age at second HSCT was 6 y.o.(1,5-20).Median time between 1 st and 2 nd allo-HSCT was 8,5 month(1-39).The CR for the second allo-HSCT was MAC in 10 pts (28%), RIC in 26 pts (72%).GVHD prophylaxis included post-transplant Cy on Days +3, +4 in 24 pts(66%),Tx/+Sir/+MMF-22 pts (61%),ATG/+Csa-7pts (19%).At the 2 nd allo-HSCT haplo-donors were chosen in 31 pts, including 5 pts with the same haplo donor as at first allo-HSCT

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