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In thyroid cancer cells, it inhibits apoptosis through the inhibition of apoptosis signal-regulating kinase 1 (ASK1) activity (72), whereas in human hepatoma it suppresses the redox-dependent activation of caspases, inducing tumor necrosis factor- (TNF)-related apoptosis-inducing ligand (TRAIL) resistance (73)

On one hand, STING activation has been shown to promote the differentiation of nave CD4 T cells into Th1 and Th9 cells and enhance the production of effector cytokines such as IFN- and IL-9, thereby augmenting CD4 T cell effector functions [229]

Berberine in obesity therapy: from molecular mechanisms to clinical applications

258 Its inhibition of 3T3-L1 adipocyte differentiation is an indirect function, involving the suppression of PPAR transcriptional activity and a decrease in reactive oxygen species (ROS) levels during early adipogenesis