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Furthermore, research indicates that CPS1, the key enzyme in the urea cycle, is predominantly expressed in hepatocytes and certain renal cells, with low or absent expression in most immune cells due to the urea cycles inactivity in these cells (134, 135)

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Targeting key signaling pathways associated with SR activationsuch as MAPK, NF-B, and JAK-STAThas been explored in clinical trials with mixed outcomes, largely due to SLE's intrinsic heterogeneity and overlapping immunopathogenic mechanisms (316, 372, 373)

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10.1093/neuonc/nou358 73 OuR.LuS.WangL.WangY.LvM.LiT.et al (2022)

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In Asian populations, such as this family of sisters, the HFE mutation is rarely detected, making awareness of FD in patients with features of genetic iron overload important

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The ICE-CBF-COR pathway in cold acclimation and AFPs in plants

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Initially, activated M1 microglia drive the inflammatory response by secreting pro-inflammatory cytokines, which contribute to extracellular matrix degradation, disruption of cell integrity, and damage to the BBB [43]

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