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Furthermore, due to questionable significance of animal data and ethical opposition to animal testing, effort has been to put into finding alternative testing methods to identify potential skin toxins 17,18,19

EXPERIMENTAL MODEL AND SUBJECT DETAILS Generation of Experimental Animals All animal experiments were performed following IACUC approved procedures (Protocols IS00003893R, IS00006358R, IS00007922R, IS00008736R, and IS00010348R)

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2019), antioxidant peptides using microorganism fermentation ( Aspergillus oryzae ) and turbot skin as substrate (Fang et al

Women who have never had children (nulliparity) are also at an increased risk (Schenken 2013)