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A 12-week cycle suits those with moderate to substantial fat loss goals or those who showed strong initial response during shorter cycles

As with other antidepressants, QT prolongation has been reported very rarely with trazodone

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Serotonin reuptake inhibition: Enhances satiety signals Reduces appetite Improves mood (reduces emotional eating) Stabilizes cravings Similar to SSRIs but different profile Potency ratios: Why triple inhibition powerful: Attacks weight loss from multiple angles Metabolic + appetite + behavioral changes Synergistic effects stronger than single pathway But also multiplies side effect risks Different from GLP-1 single mechanism Compare to semaglutide mechanism and other weight loss approaches