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Two 2013 systematic reviews of interventions concluded that the modest benefit of propionyl-L-carnitine on walking performance was equivalent or superior to that obtained with drugs approved for claudication in the US (e.g., pentoxyphylline, cilostazol) yet inferior to improvements seen with supervised exercise interventions (69, 70)

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Notably, it has been noted that a number of piRNA pathway proteins localize into the nucleus, including MIWI2, TDRD9, and MAEL [438, 442,443,444]

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Mori et al., 2009) (Figure 1)