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Research progress of natural plant polysaccharides inhibiting inflammatory signaling pathways and regulating intestinal flora and metabolism to protect inflammatory bowel disease

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acnes can stimulate adaptive immune responses by inducing the secretion of pro-inflammatory cytokines (Ozlu et al., 2016), activation of inflammasomes ( C

It causes extensive DNA damage and variations, impairs protein functions, and disrupts cellular signaling pathways

High levels of Ca 2+ are brought to the nucleus by CaM where it will cause DNA fragmentation and lead to necrosis (Nicotera et al

In vivo xenograft model Pathogen-free female BALB/c mice (aged 56 weeks) were purchased from the Shanghai Laboratory Animal Center, CAS (Shanghai, China)