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Moreover, paclitaxel causes photodistributed rash, erythema, hyperpigmentation, and photoonycholysis [224,225]

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Upon binding to an uncharged tRNA, GCN2 undergoes a conformational change and is activated, resulting in inhibitory phosphorylation of eukaryotic translation initiation factor 2 (eIF2), preventing translation initiation under amino acid deficiency (Figure 1) (Berlanga et al., 1999

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