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Nutrients 16(15):2476

RJC and CPV provided the AAV vector and helped with conceptual input for experiments

GPX4 is vital in the survival and expansion of recently activated T-cells by prevention of lipid peroxidation and ferroptotic cell death (Reference Matsushita, Freigang and Schneider72)

That these relationships were seen in hepatocytes, myocytes, and brown adipocytes, but were conspicuously absent in fibroblasts, hints that oxidative metabolism might represent an intrinsic challenge to ER functionality and might explain why feeding itself appears to be an ER stressor