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Renin plays a role in converting angiotensinogen to angiotensin I, which is then converted to angiotensin IIa potent vasoconstrictor

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Furthermore, the recently initiated FINEARTS-HF (ClinicalTrial.gov: NCT04435626), investigating the width of the HFpEF phenotype, is powered to detect changes in incidence of first and recurrent hospitalization due to heart failure and cardiovascular mortality, and results are expected to highlight the potential of MRAs as preventive of HFrEF and possibly as a therapeutic in HFpEF