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AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1 -independent manner

A recent study described a reduction in miR-9 expression in CRC cell lines under high glucose concentrations (95)

Together, these two may serve as primary pro-ferroptotic drivers

Garcia Segarra N, Roche S, Imbard A et al

Smith GD

Remarkably, a study by Escribano et al revealed that, when compared with the control group, children with severe AATD showed significantly increased levels of oxidative stress biomarkers and decreased levels of antioxidants, as expressed by lower total and reduced glutathione levels, decreased catalase activity, and increased glutathione peroxidase activity