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Although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible if left untreated

Pernicious anaemia, atrophic gastritis, proton pump inhibitors, metformin, and gastrointestinal surgery significantly impair B12 absorption

The National Institute of Health (NIH) recommends that healthy adults get 2.4 micrograms of Vitamin B12 each day

This is caused by the lack of B12 in our body

However, their activity consumes significant amounts of NAD + , leading to a depletion of cellular NAD + levels and impacting energy metabolism and cell survival 58