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However, unfavorable effects of ALDH2*2 allele have been reported in terms of the risk of some diseases such as osteoporosis [25] and neurodegenerative diseases [24, 26, 27]

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Recent studies have also explored the use of combination therapies that incorporate novel agents targeting specific cellular mechanisms, such as mitophagy ( Future research may focus on identifying optimal drug combinations tailored to individual patient profiles

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NTZ, especially at the higher dose, elicited similar hepatoprotective effects comparable to NAC and 4-PBA, indicating the possible involvement of ER stress modulation in NTZ-elicited hepatoprotective effects

Studies using ghr KO mice showed significantly decreased body mass as well as smaller liver and brain mass/size than control mice (250, 310, 314319) and growth delay (250, 254)