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Understanding the mechanisms that lead to decreased mitochondrial activity in insulin-sensitive tissues is important for developing therapies to reverse insulin resistance

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These studies show the combined value of animal and human studies

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PMID 15572661

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50 The consistent findings may be due to the fact that L-carnitine is a nonessential amino acid, which the body can synthesize from other amino acids in presence of other micronutrients

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Since TMABADH.1S could be expressed well and showed about 0.9 U mg 1 activity, it was selected for further work on the carnitine biosynthetic pathway

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