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doi: 10.3390/jcm9093057 25 van WoerkomJMKruizeAAWenting-van WijkMJKnolEBihariICJacobsJWet al

Lean non-alcoholic fatty liver disease Although most often comorbid with obesity, metabolic liver disease can occur in patients with normal body weight/BMI, termed lean NAFLD (LNAFLD)

Indeed, in several studies it has been proposed that GST polymorphisms may be used as biomarkers for prognosis in cancer patients 39,45

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In the chimeric tyrosine kinase (3T3 EN) transformed 3T3 KRAS V12 cell line [54, 55], and under exogenous oxidative stress conditions when tracking SLC7A11 expression using the system Xc- tracer (18)F-5-fluoroaminosuberic acid ((18)F-FASu) [56, 57], it was found that the expression and activity of SLC7A11 appeared upregulated in the 3T3 KRAS V12 cell line compared to the normal cell line [58]