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High doses of inactive pyridoxine can actually be neurotoxic over time

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The higher transduction efficiencies resulted in total unsupported hemoglobin levels of 10.63 g/dL (9.614.0, n = 16) in the transfusion-independent patients, the majority of which corresponded to the therapeutic transgene HbA T87Q (9.083: 4.6812.43 g/dL, n = 16)