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The application of synthetic cannabinoids (e.g., WIN55,212-2) were able to reduce the microglial release of these factors and directly act on primary astrocyte cells from mice to reduce hemichannel activation, preventing astrocytic uncoupling and maintaining gap junctions (Froger et al., 2009

J Environ Sci Health B 55(11):959967

Overall, the evidence indicates that curcumin acts as a multifaceted epigenetic modulator

That is, TZDs restrained ACSL4 to block the enzymatic reaction during LPO, thus interfering with ferroptosis in vivo and in vitro (Doll et al

The thiols cysteine and GSH are involved in the redox process through a disulfide conversion system that leads to the homeostasis of oxidative stress in plants [13]

Moreover, several platform technologies described herein may serve as plug-and-play technologies that can be tailored to seasonal or new strains of coronaviruses