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One of the most important defense we have against any disease is our gut microbiome, which is constantly assaulted by a range of toxins, parasites, bacteria and fungi that we inevitably ingest

Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na + -dependent glutamate uptake

PX-12 achieves a reduction in TXN1 activity either by covalently binding to the key cysteine residue Cys73 in TXN1 or by enhancing the dimerization of its oxidized form [225]

TABLE 4 Results of Histopathological scoring in all the study groups

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Parallel to identification of Mn neurotoxic properties, neuroprotective strategies have been reported, and these include endogenous antioxidants (for instance, vitamin E), plant extracts (complex mixtures containing polyphenols and non-characterized components), iron chelating agents, precursors of glutathione (GSH), and synthetic compounds that can experimentally afford protection against Mn-induced neurotoxicity