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Free Radic Biol Med 115:30917 Vucic S, Henderson RD, Mathers S, Needham M, Schultz D, Kiernan MC et al (2021) Safety and efficacy of dimethyl fumarate in ALS: randomised controlled study

[Abstract]2023 Oct 12;66(19):13556-13567

The therapies include systemic therapy (especially temozolomide chemotherapy), radiotherapy, immunotherapy, and nanotherapy

Reconstituting with SWFI means the solution will have a much shorter shelf life (typically 24-72 hours when refrigerated) before microbial growth becomes a concern

Chronic hypoxia induces a vicious cycle of decreased PP2A activity and increased p--syn We have found that hypoxia promoted -syn phosphorylation, but the molecular mechanism remained unclear