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Frieman, M

358 Abnormal expression of transport proteins/receptors in the BBB, such as downregulation of LRP1 which exports A from the brain to the blood, impaired function of Pgp, and upregulation of RAGE that facilitates the entry of A from the blood into the brain, could be potential reasons for impaired A clearance and substantial accumulation in the brain

For certain lipogenic genes, however, the reversal of downregulated expression was not complete (Fig

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