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29,30 In 1985, oxidative stress was defined as a cellular imbalance between oxidants and reductants, leading to the differentiation of eustress and distress to describe oxidative stress states under physiological and pathological conditions, thereby advancing our understanding of oxidative stress in human diseases

doi: 10.3389/fnut.2025.1699218 Received 05 September 2025 Accepted 20 October 2025 Published 04 November 2025 Volume 12 - 2025 Edited by Hui-Xin Liu, China Medical University, China Reviewed by Shao-Yu Yang, National Taiwan University Hospital, Taiwan Alice Ngu, University of Nebraska Medical Center, United States Updates Copyright 2025 Li, Cao, Gao, Liang, Ma, Liu, Wang and Wei

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Khavinsons work focused on extracting bioactive compounds from the pineal gland, leading to the identification of naturally occurring peptides that appeared to influence aging processes