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two published tirzepatide case series (Naranjo "probable"), FAERS reporting odds ratio 22.55 for allodynia across GLP-1 with tirzepatides neuro-AE proportion lower than semaglutides, class cohort signal (aHR 2.15) in related agents

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Research has also found that SAT1 induction is associated with the expression of arachidonate 15-lipoxygenase (ALOX15), which is essential in p53-mediated ferroptosis ( The metabolism of glutamine, one of the essential components of ferroptosis, is catalyzed by cytosolic glutamine aminotransferases or by mitochondrial glutaminases ( Colorectal cancer (CRC) caused by a number of genetic disorders, including KRAS mutation, p53 mutation, and p53 depletion, which provides additional evidence for the survival-promoting function of p53

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The treatment efficacy on pain was evaluated using VAS, Total Symptom Score (TSS), Clinical Global Impression of Change, McGill Pain Questionnaire (MPQ), and the need for rescue analgesics