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In some cases, more aggressive treatment protocols are recommended

HMW-HA demonstrates anti-inflammatory effects, whereas LMW-HA encourages inflammation [5]

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229,230 Interestingly, in a patient with SCO2 mutations who presented with severe hypertrophic cardiomyopathy, Cu-histidine supplementation has been reported to improve heart function, showing attenuated cardiomyopathy as well as the normalization of blood pressure