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and 8) which has recently been recognized as one of the hallmarks of cancer, can also contribute to the evasion of the antitumor immune response ( Reprogrammed metabolic activities of tumor cells that support survival, maintenance, and drug response are related to altered bioenergetic pathways, enhanced macromolecule biosynthesis, and maintenance of the redox balance (Vander Heiden and Deberardinis, 2017)

2016 PMC4912392 Borges, GT

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Figure 9 Taken together, these results indicate that in mammalian somatotrophs, nesfatins play an inhibitory role on GH synthesis and secretion, although their physiological significance, for example in humans, has not yet been established