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A pivotal role of ageing in triggering neurodegenerative disease critically involving lysosomal mechanisms is consistent with genes that cause a congenital devastating lysosomal storage disorder (LSD) when homozygously mutated, but are also major risk factors for a late age-onset neurodegenerative disorder, such as PD (for example, GB1 ) or frontotemporal dementia (FTD) (for example, GRN ), when only one mutant copy is inherited 39,40

Acknowledgements The authors are grateful for the collaboration of the National Institute of Oceanography and Fisheries (NIOF), Egypt and Benha University

Microorganisms 11 , 2019 (2023)

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The cost of peptide therapy in Los Angeles usually ranges from $150 to $5,000

Listed as a prohibited substance by WADA (World Anti-Doping Agency)