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NAD + is also produced through salvage pathways from nicotinamide and nicotinamide riboside precursors, however, people with deficiency or low activity of the GS gene exhibit severe secondary NAD + deficiency (Reference Hu, Ibrahim and Stucki15) , indicating that the glutamine supply is indispensable for NAD + synthesis (Reference Wojcik, Seidle and Bieganowski16)

Li J, Sun Y, Jiang X, Chen B, Zhang X (2018) Arbuscular mycorrhizal fungi alleviate arsenic toxicity to Medicago sativa by influencing arsenic speciation and partitioning

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The Nrf2 signaling pathway protects cells from oxidative stress by activating its target gene, heme oxygenase-1 (HO-1), in response to oxidative stress induced by both UVA and H 2 O 2 [66, 67]

[DOI] [PMC free article] [PubMed] [Google Scholar] Nagata K