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Clinical relevance of MTHFR, eNOS, ACE, and ApoE gene polymorphisms and serum vitamin profile among Malay patients with ischemic stroke

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Therefore, parenteral cyanocobalamin should be administered to a pregnant woman if the benefits outweigh the risks.[15][16] Cyanocobalamin is excreted in the breast milk of nursing women in levels similar to the level of vitamin B12 in maternal plasma.[25] The distributed cyanocobalamin in breast milk has been found to be compatible with breastfeeding by the American Academy of Pediatrics.[26] In addition, there has not been any reports of adverse effects associated with the intake of normal daily requirements of vitamin B12 during lactation

If neurological involvement is suspected, treatment should be started urgently and must not be delayed whilst awaiting blood test results

In the POLLUX clinical trial, patients with relapsed or refractory multiple myeloma who received the combination of the anti-CD38 antibody daratumumab with lenalidomide and dexamethasone had significantly prolonged progression-free survival (PFS) relative to those who received lenalidomide and dexamethasone alone

Liak C, Fitzpatrick M