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Additionally, further exploration of the role of topiramate in modulating this pathway, particularly its dose-dependent effects, is necessary

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Under optimal conditions, follow-up visits were scheduled every 3 months during the first year (34)

Additionally, tyrosines play an important role in aSyn-vesicle binding while nitration impairs this interaction (making the charge more negative at the N-terminal domain, or causing a conformational change when the C-terminal domain is nitrated) thereby increasing the amount of aSyn in a random coil or beta-sheet conformation and thus shifting equilibrium toward oligomer formation 105,106,109

La L -Carnitina es un aminocido que desempea un papel crucial en el transporte de cidos grasos hacia las mitocondrias , las cuales son los orgnulos encargados de producir la energa necesaria para las actividades celulares