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Elderly patients infected with SARS-CoV-2 frequently experience rapid disease progression due to high expression of PD-1 and Tim-3 on CD8 + T cells and dysregulated innate immunity, culminating in cytokine storms dominated by IL-6 and granulocytemacrophage colonystimulating factor (GM-CSF)

JAMA 1971;215:1671

however, this captures only a part of the overall complexity of individual variation

In Wister albino rats weighing approximately 200 g, 600 mg/kg of APAP administration significantly increased ALT, AST, cholesterol, and low-density lipoprotein, which were attenuated to near normal ranges when administrated 50 and 75 mg/kg of Prosopis farcta (Banks & Sol.) J.F.Macbr

*Correspondence: Weihui Lu, [email protected]

In this issue of the JCI, Thimmulappa et al